Archieven

Academic Medical Center Amsterdam – Clinical Chemistry / Woman and Child / Endocrinology

PO Box 22660, 1100DD Amsterdam / Meibergdreef 9, 1100AZ Amsterdam, NL

Contact:
Henk Schierbeek
h.schierbeek@amc.uva.nl
31(0)205666299

Research line
Health and Disease

Topics
metabolic kinetics
amino acids, peptides, carbohydrates, protein synthesis, energy expenditure
neonates, adults, laboratory animals: mouse, rat, pig, baboon
insulin resistance, lungs (surfactant), gut, oxidative stress and malnutrition

Isotopes
¹³C, ¹⁵N, ¹⁸O, ²H

Instruments
LC/MS/MS, GC/MS/MS, GC/C/IRMS, EA/C/IRMS, SIRIS, GC/MS, LC/C/IRMS

LCMS\MS, Waters, Premier, Triple quad
LCMS\MS, Waters, Xevo, Triple quad
LCMS\MS, Thermo Fisher, Velos pro, Linear Trap
GCMS\MS, Agilent 7000 GC\QQQ, Triple quad
GCMS, Agilent 5975C, Single quad
GCMS, Agilent 5973, Single quad
GCMS, Agilent 5973, Single quad
IRMS, Thermo Fisher, Delta plus
– GC/C/IRMS (+ Headspace)
IRMS, Thermo Fisher, Delta XP plus
– GC/C/IRMS
– LC/C/IRMS
– TCEA/IRMS
– Con Flow EA/IRMS
Infrared Spectrometer, Fisher, Helifan, CO₂ analysis

Ghent University Faculty of Medicine – Doping Control Laboratory

Technologiepark 30, 9052 Zwijnaarde, B

Contact
Michaël Polet
michael.polet@ugent.be
32(0)93313296

Research line
Doping control

Topics
distinguish between endogenous steroids and their synthetic copies
improving the existing methods
expanding them with new compounds.

Isotopes
¹³C

Instruments
GC/C/IRMS

ThermoScientific, MAT253

Ghent University – Isotope Bioscience Laboratory (ISOFYS)

Coupure Links 653, 9000 Gent, B

Contact
Prof. Pascal Boeckx
Pascal.Boeckx@UGent.be
Ugent Stable Isotope Facility
32(0)92646000

Research line
Analytical development, Ecology, Geology

Topics
agronomy, biogeochemistry, ecology, paleoclimatology, hydrology, climate change impacts and adaptation, soil conservation and isotope forensics
new analytical protocols for stable isotopes

Isotopes
¹³C, ¹⁵N, ¹⁸O, ²H

Instruments
EA/C/IRMS, TC-EA/IRMS, TG-IRMS, GC/C/IRMS, LC/C/IRMS, SIRIS

EA-IRMS: ANCA-SL (Autom N C Analyser – Solids and Liquids) / SerCon 20-20 IRMS (SysCon electronics)
TC-EA-IRMS: A Sercon ht furnace (1400ºC thermal decomp elem analyser) / Sercon 20-20 IRMS (SysCon electronics)
TG-IRMS: ANCA-TGII (Autom N C Analyser – Trace Gases) / SerCon 20-20 IRMS (SysCon electronics) with cryogenic trapping and focusing of samples
GC-IRMS: A Finnigan Trace GC Ultra with combustion interface (GC combustion III) coupled to a Finnigan DeltaplusXP
LC-IRMS: A Finnigan Surveyor HPLC with LC-IsoLINK interface coupled to a Finnigan DeltaPLUSXP
Wavelength-Scanned Cavity Ring-Down Spectroscopy Analyser Isotopic Water Analyser: Model L1102-i, Picarro

Groningen University Medical Center – Center for Liver, Digestive and Metabolic diseases

PO Box 30.001, 9700 RB Groningen
Hanzeplein 1, 9713GZ Groningen, NL

Contact
Bert Groen
a.k.groen@umcg.nl
31(0)503632669

Research line
Health and Disease

Topics
Arteriosclerosis (cholesterol and bile acid metabolism)
Diabetes Mellitus (glucose, lipid metabolism)
men, rats, various mouse models and cell cultures
regulation of metabolic pathways
kinetics of metabolic pathways applying tracer technology
colon delivery device
cholesterol, bile acids, glucose, palmitic acid, stearic acid, oleic acid, urea, bicarbonate, breath CO₂kinetic studies in mouse blood, requiring frequent sampling of minimal blood spots

Isotopes
¹³C, ¹⁵N, ²H

Instruments
GC/C/IRMS, GC/P/IRMS, GC/MS, LC/MS/MS

Agilent 6890 GC/ Finnigan DeltaplusXL IRMS with CTC Pal autosampler
Two Agilent 6890 GC/ 5975 quadrupole MS with CTC Pal auto sampler
Perkin ElmerLC/API 3000 MS/MS with Perkin Elmer auto sampler
Shimadzu LC/API 3000 MS/MS with Shimadzu auto sampler

KU Leuven – Department of Clinical and Experimental Medicine

O&N1, box 701 / Herestraat 49, 3000 Leuven, B

Contact
Prof. Kristin Verbeke
kristin.verbeke@med.kuleuven.be
32(0)16330150

Research line
Health and disease

Topics
Estimation of colonic short chain fatty acid production
Analysis of colonic ammonia metabolism using ¹⁵N-labelled lactose ureide
Breath tests using ¹³C-labelled substrates

Isotopes
¹³C, ¹⁵N

Instruments
GC/IRMS, EA/C/IRMS, GC/C/IRMS

ABCA (Sercon, UK)
ANCA (Sercon, UK)
GC-C-IRMS (Thermo)

KU Leuven – Department of Earth & Environmental Sciences

Celestijnenlaan 200E, 3001 Leuven, B

Contact
Steven Bouillon
Steven.Bouillon@ees.kuleuven.be
32(0)498513608

Research line
Ecology, Biogeochemistry

Topics
Biogeochemistry
Terrestrial and aquatic biogeochemistry – both natural abundance and tracer experiments.

Isotopes
¹³C, ¹⁵N, ¹⁸O, ³²S

δ¹³C (organic matter, dissolved inorganic carbon, dissolved organic carbon
dissolved CH₄, carbonates, specific compounds)
δ¹⁵N (organic matter, dissolved N₂)
δ¹⁸O (H₂O, dissolved O₂)
δ³⁴S (organic matter)

Instruments
EA/C/IRMS, GC/C/IRMS, TOC/IRMS

Liège University – Dept. Biology Ecology Evolution

Liège University – Freshwater and OCeanic science Unit of reSearch (FOCUS)

Institute of Chemistry (Building B6c), 13 Allée du 6 Août, Quartier Agora, Sart-Tilman Campus, 4000 Liège, Belgium

Contact
Gilles Lepoint
g.lepoint@uliege.be
32(0)43663327

Loïc Michel
loic.michel@uliege.be
32(0)43663322

Research line
Ecology

Topics
Food webs (mostly marine, but also freshwater or terrestrial), ecology, ocean sciences, environmental and earth sciences, plant and animal ecology and physiology, pollution & ecotoxicology

Isotopes
¹³C, ¹⁵N, ³²S

Instruments
EA/C/IRMS, GC/C/IRMS

EA/IRMS, vario MICRO cube & IsoPrime precisION (Elementar)
GC/C/IRMS, Agilent 7890A & IsoPrime100 (Elementar)

Maastricht University – Human biology, Movement Sciences

PO Box 616, 6200 MD Maastricht
Universiteitssingel 50, 6229 ER Maastricht, NL

Contact
Luc van Loon
L.vanLoon@maastrichtuniversity.nl
31(0)433881397 /31(0)613260552

Ellen Blaak
e.blaak@maastrichtuniversity.nl

http://www.m3-research.nl
http://www.sirc.unimaas.nl

Research line
Health and Disease

Topics
protein, carbohydrate and fat and metabolism in vivo in humans
(nutritional) intervention studies
to assess substrate fluxes in different physiological situations and/or patient groups.

Isotopes
¹³C, ¹⁵N, ²H

Instruments
GC/C/IRMS, GC/MS

·        Thermo Scientific MAT-253 GC combustion IRMS
·        Agilent GC-MS (GC:7870A; MS:5975C) (Electron Impact mode)
·        Agilent GC-MS (GC: 6890N; MS: 5973) (EI- and CI-mode)
·        Finnigan DELTAplus GC combustion IRMS with detectors for CO₂ and N₂.

GC-C-IRMS:
·        Enrichment of breath CO₂·        Concentration and enrichment of CO2 in blood samples
·        Deuterated water enrichment
·        Enrichment of ¹³C-labeled glucose and fatty acids in plasma samples and muscle extracts
·        Enrichment of ¹³C-labeled fatty acids in plasma FFA and plasma triglycerides and in the different lipid fractions of muscle
·        Enrichment of ¹³C- and ¹⁵N-labeled amino acids in plasma samples, in mixed muscle protein and albumin samples.

GC-MS:
·        Plasma enrichment of [²H₅]glycerol, [U-¹³C]glycerol, [1-¹³C]KIC, [6,6-²H₂]glucose,
[²H₂]palmitate (enrichment in plasma FFA and triglycerides), [²H5-ring]phenylalanine, [1-¹³C]phenylalanine, [1-¹³C]leucine,
[1-¹³C]tyrosine [2H₂]tyrosine and [2H₄]tyrosine,
·        Concentrations of phenylalanine, tyrosine and leucine
·        [²H₂]tyrosine
·        [U¹³C]phenylalanine
·        [²H₅]phenylalanine
·        Intrinsically [1-¹³C]phenylalanine and [1-¹³C]leucine labeled milk protein
·        [²H₂]glucose
·        [U¹³C]glucose
·        [²H₂]palmitate
·        [U¹³C]palmitate
·        [²H₅]-glycerol

Netherlands Forensic Institute – Microscopic Traces

PO Box 24044, 2490 AA Den Haag
Laan van Ypenburg 6, 2497 GB Den Haag

Contact
Gerard van der Peijl
g.van.der.peijl@nfi.minvenj.nl
31(0)708886478

Research line
Human forensics

Topics
Comparative analyses of different materials
mainly tapes, but also explosives, fibers, textiles,
paints, papers, inks, plastics or adhesives in general.

Isotopes
¹³C, ¹⁵N, ¹⁸O, ²H

Instruments
GC/C/IRMS/MS, EA/C/IRMS
GC-IRMS/MS (Agilent 7890 GC, ThermoFisher Mat 253 IRMS, ISQ Quadrupole MS, Interface ConFlo IV);
EA-IRMS (TC/EA und Flash EA 112, ThermoFisher Delta V advantage IRMS, Interface ConFlo IV)

Research Institute for Chromatography – Research & Development

Pres. Kennedypark 26
8500 Kortrijk, Belgium

Contact
Emmie Dumont
emmied@richrom.com
32(0)56204031

Research line
Analytical development

Topics
optimization of the chromatographic separation before IRMS
implementation of 2D-GC and 2D-LC
complex natural samples.

Isotopes
¹³C, ¹⁵N, ²H

Instruments
GC/Py/IRMS, 2D-GC/Py/IRMS, LC/C/IRMS

GC-C/Py-IRMS (Agilent GC 7890 + Thermo delta V advantage)
2D-GC-C/Py-IRMS
LC-C-IRMS (All Thermo)

Taal: